Abstract
A fragment of Tn 1331 including tnpR, aac, aadA,and abla gene which encodes lower levels of resistance to ampicillin and carbenicillin as compared to those mediated by the TEM β-lactamase was sequenced. The polypeptide encoded by the bla gene has homology with the OXA-1, PSE-2, and OXA-2 proteins. Genes aac and bla are upstream and downstream respectively of aadA, and are both flanked by recombinational hot spots. Tn 1331 has 520-bp direct repeats which include parts of the tnpR and TEM bla genes. Evolutionary models for the genesis of Tn 1331 are proposed.
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