Abstract
We have determined nucleotide sequences of large regions of SV40 DNA including those spanning the 3′ ends and 5′ ends of “early” and “late” mRNA and the region in which DNA replication begins. The sequences indicate that several percent of the viral genome is untranslated. These untranslated regions contain curious features such as a region of partial homology between the 3′ sequences of SV40 and the 3′ terminal sequences reported for rabbit hemoglobin B chain mRNA, symmetric sequences at or near the origin of DNA replication, and some prominent repeats, including an identical repeat of 21 nucleotides near the origin of DNA replication. Stretches of 6 or more deoxyadenylic acids in the DNA appear to be preferentially located on the strand whose transcript is not represented in stable mRNA and occur near the 3′ and 5′ ends of both “early” and “late” mRNA.
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