Abstract
Prolactin or luteotropic hormone (PRL) is a protein hormone. Hyperprolactinemia is
 one of the most common endocrine disorders. We initiate to investigate if the genetic
 factor was behind some of the infertile cases suffering from hyperprolactinemia in slemani
 city. For this study, 36 samples from infertile women were taken and the genomic DNA
 was isolated. We desgined specific polynucleotide primers to amplify a portion of the PRL
 gene using PCR technique. The PCR products were subjected for DNA sequencing
 together with PCR products of 15 samples from healthy individuals. Silent mutations were
 found between individuals, but non of them correlated to the PRL gene variations between
 healthy and hyperprolactinemic cases. We perform promoter analysis of the PRL gene
 using Bioinformatics approcach to identify/determine specific transcription regulator(s) of
 the PRL gene.
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