Abstract
Ceftazidime–avibactam resistance among carbapenem-resistant Klebsiella pneumoniae at our hospital has emerged in sequence type (ST)-258, clade II isolates. We investigated hypermutability of ST258, clade II (n = 6) and clade I K. pneumoniae (n = 8) using a standard rifampin assay. Mutational frequencies were ≤10–7.1, indicating that isolates were not hypermutators. Mutational frequencies did not differ between clade II and I isolates. Ceftazidime–avibactam resistance among ST258, clade II K. pneumoniae is most likely a reflection of our hospital's ecology.
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