Year-end Sale % OFF 
Abstract
This study is devoted to interactions of oligonucleotides containing specific DNA motifs with and transport into human endothelial cells. Those motifs are overrepresented in a pool of short DNA firmly bound to the surfaces of these cells. The data obtained by various methods suggest that the binding of oligonucleotides to the cell membrane and their accumulation in endothelial cells depend on both the presence of specific DNA motifs (CATGCAT, GATCCA, or TACGT) and their combination in the oligonucleotides under study. The oligonucleotides penetrate into endothelial cells via receptor-mediated endocytosis, which is confirmed by flow cytometry and fluorescence microscopy in the presence of potential inhibitors and competitors of intracellular transport.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
