Abstract
Recruitment drive: A 12 mer peptide nucleic acid(PNA)–flavin conjugate is prepared. When the PNA moiety is hybridized to its complementary sequence in a 25 mer oligo-2′-deoxyribonucleotide, the flavin moiety can recruit an NADPH:flavin oxidoreductase. This complex allows the activation of molecular oxygen in the presence of NADH and the selective oxidation of the oligonucleotide target (see scheme).
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