Abstract
The synthesis and characterization of poly[Leu-Leu-(ε-Z)-Lys] and its conformational study in organic solvents are reported. The sequential polypeptide has been obtained with a satisfactory optical purity by the self-condensation method of the p-nitrophenyl ester of the corresponding tripeptide derivative according to the general procedure of De Tar et al. Poly[Leu-Leu-(ε-Z)-Lys] showed a right-handed α-helical conformation in solution of helicogenic solvents, as displayed by circular dichroism measurements and ultra-violet absorption spectra. The presence of the α-helix has been also detected in the solid state by infra-red spectroscopy. The helix stability of the polypeptide in chloroform—dichloroacetic acid solution is considerably high. This property may be related to the ordered sequence of the bulky leucyl residues which give rise to a screening effect, protecting the chain backbone from the acid solvent molecules.
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