Abstract
Torsion unconstrained double-stranded DNA can undergo an “overstretching” transition at forces around 65 pN, which elongates the DNA backbone by about 1.7-fold. Recent experiments have revealed two distinct structural transitions during DNA overstretching: a “peeling” of one strand from the other leads to a single-stranded DNA, and a “B-to-S” transition to a mysterious double-stranded “S-DNA”. The peeling transition has been determined to depend on DNA sequence. The knowledge of sequence dependence of the B-to-S transition, however, is still lacking. Here, we report for the first time that, the GC-rich DNA requires a slight higher transition force compare to the AT-rich DNA. This finding helps us to understand the structure of the mysterious double-stranded S-DNA.
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