Abstract
Two new cyclooctapeptides, cherimolacyclopeptide A, cyclo(Pro1-Gln2-Thr3-Gly4-Met5-Leu6-Pro7-Ile8-) (1) and the related cherimolacyclopeptide B, cyclo(Pro1-Gln2-Thr3-Gly4-Mso5-Leu6-Pro7-Ile8-) (2), have been isolated from the methanol extract of the seeds of Annona cherimola Miller. The sequences were elucidated on the basis of the MS/MS fragmentation, using a Q-TOF mass spectrometer equipped with an ESI source, chemical degradation and extensive 2D-heteronuclear NMR. The three-dimensional solution structure of cherimolacyclopeptide A (1) determined by 1H NMR data and molecular modelling is characterised by the presence of two β turns and a new type of β-bulge.
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