Sequence and Possible Function of a Novel Ca2+-Binding Protein Encoded in the Shaker-Locus of Drosophila

Abstract

In the 1960s, the multifaceted role of cyclic nucleotides and their associated phosphorylation systems became apparent Similar second messenger functions for Ca2+ were also suggested. In certain favorable instances, such as muscle contraction and neurotransmitter release, these were actually established. The role of Ca2+ in the control of neurotransmitter release has been investigated in great detail. In addition, the control of neuronal excitability and plasticity are of special interest. An effect of Ca2+ on the gating of voltage-gated ion channels has been suggested, but little is known about the initial Ca2+ receptor molecules along the stimulus-response pathway which decodes the information contained in a Ca2+ transient and which translates it into an effect on the gating of ion channels.