Abstract
A/Taiwan/1/86 is representative of newly emerged antigenic variants of influenza A(H1N1) viruses which are readily distinguishable from all previous A(H1N1) isolates. Nucleotide sequence analysis of the haemagglutinin HA1 coding region of A/Taiwan/1/86 suggests that this virus has evolved from viruses circulating in the Hong Kong region in 1982 to 1983. The considerable alteration in antigenicity of this new isolate is likely to have arisen from five amino acid substitutions in a nine amino acid stretch, situated on the outer surface of a short alpha-helix on the tip of the HA molecule in antigenic site Sb.
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