Septic Shock in Pediatrics

Tarek Attia,Maysaa Saeed

doi:10.21608/aeji.2015.17853

Abstract

Sepsis is defined as a clinical syndrome that complicates severe infection and is associated with the systemic inflammatory response syndrome as well as immune dysregulation. Circulatory decompensation and end-organ dysfunction will be the ultimate end if sepsis is not properly managed. In this syndrome, tissues remote from the original insult display the cardinal signs of inflammation, including vasodilation, increased microvascular permeability and leukocyte accumulation. Recently pediatric mortality from severe sepsis and septic shock has markedly decreased because of early recognition, aggressive fluid therapy and early administration of vasoactive agents in addition to antibiotics.

Highlights

Sepsis is defined as a clinical syndrome that complicates severe infection and is associated with the systemic inflammatory response syndrome as well as immune dysregulation
Pediatric sepsis is generally considered to comprise a spectrum of disorders that result from infection by bacteria, viruses, fungi, or parasites or the toxic products of these microorganisms
The spectrum of sepsis ranges from microbial invasion of the bloodstream or intoxication with early signs of circulatory compromise including tachycardia, tachypnea, peripheral vasodilation, and fever to full-blown circulatory collapse with multiple organ dysfunction syndrome (MODS) and death [3]

Summary

Introduction

Sepsis is defined as a clinical syndrome that complicates severe infection and is associated with the systemic inflammatory response syndrome as well as immune dysregulation. Pediatric mortality from severe sepsis and septic shock has markedly decreased because of early recognition, aggressive fluid therapy and early administration of vasoactive agents in addition to antibiotics.

Results

Conclusion