Abstract
Furie et al. measured serial levels of prothrombin fragment F1.2, a marker of thrombin generation, in 320 patients enrolled in the Warfarin Aspirin Recurrent Stroke Study (WARSS). Mean F1.2 levels did not differ by stroke subtype at baseline, but changes in F1.2 over time did vary by stroke mechanism. F1.2 levels were associated with vascular risk factors and were suppressed by warfarin in a dose-dependent fashion. There was a trend toward a higher risk of recurrent stroke or death as F1.2 levels increased. see page 777 The accompanying editorial by Gregory del Zoppo reviews the activation of the coagulation cascade to ask, “Can a marker of thrombin generation be used as an indicator of stroke etiology?”—and can strokes with unassigned etiology be identified by evidence of thrombosis? He further notes that while a causal relationship between cryptogenic stroke and increased PF1.2 levels was not revealed by this study, thrombin may still be important. see page 768 Ohtake et al. screened sporadic and familial …
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