Abstract
Background The lateral septum (LS) has been shown to play an important role in the generation and modulation of behavioural and neuroendocrine stress responses. However, the exact neurochemical mechanisms mediating these effects are not well studied so far. Several lines of evidence suggest a robust contribution of septal urocortin 3 (UCN3) and its preferred receptor, the corticotropin-releasing factor type 2 (CRF2) receptor in mediating these effects. Therefore, the aim of the present study was to examine the role of septal CRF2 receptors in neuroendocrine and behavioural stress responses.
Highlights
The lateral septum (LS) has been shown to play an important role in the generation and modulation of behavioural and neuroendocrine stress responses
Male Sprague-Dawley rats implanted with a jugular venous catheter and a microinjection cannula aimed at the LS received bilateral injections of either urocortin 3 (UCN3), the selective corticotropin-releasing factor type 2 (CRF2) receptor antagonist anti-sauvagine-30 (ASV-30) or vehicle, and were exposed to forced swim stress
Our data show that intraseptal UCN3 infusion reduced active coping and increased immobility during the forced swim exposure as UCN3 treated animals showed less struggling and swimming behaviour and increased floating behaviour compared to controls
Summary
The lateral septum (LS) has been shown to play an important role in the generation and modulation of behavioural and neuroendocrine stress responses. Septal urocortin 3 modulates stress-coping behaviour but not hypothalamic-pituitary-adrenal axis activity during forced swimming From 17th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint meeting with the Hungarian Society of Experimental and Clinical Pharmacology (MFT) Innsbruck, Austria.
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