Septal angle on MRI predicts combined pre- and post-capillary pulmonary hypertension

Abstract

Purpose: Patients with left heart disease commonly develop pulmonary hypertension (PH), and some subsequently develop pre-capillary vascular remodelling. This combined pre- and post-capillary pulmonary hypertension (Cpc-PH) is defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg, pulmonary arterial wedge pressure (PAWP) >15 mmHg and diastolic pulmonary gradient (DPG) of ≥7. Patients with Cpc-PH have a worse outcome and targeted pulmonary vascular therapies may be useful. The aim of this study was to assess the role of magnetic resonance imaging (MRI) septal angle in Cpc-PH.