Abstract
SEPT12, a member of the Septin gene family, has expression restricted to the testis and is critical for normal spermatogenesis. Septin genes code for polymerizing guanosine triphosphate (GTP) binding proteins whose homologs have been conserved throughout evolution from yeast to humans (1). Roles assigned to Septin genes include cell division, cytoskeletal organization, and membrane-remodeling events including the epithelial-mesenchymal transition in metastatic cancers (2). A study that investigated azoospermia and teratozoospermia in a mouse knockout model demonstrated oocytes fertilized via ICSI with sperm targeted SEPT12 antisense alleles resulted in embryo arrest by the morula stage (3).
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