Sepsis

Abstract

The burden of sepsis on our health care system is significant, with approximately 750,000 cases per year in the United States, 215,000 resultant deaths, and annual costs of $16.7 billion nationally (1). Organ failure is a significant contributor to mortality, with renal failure occurring in approximately 15% of patients (2). In a large registry of critically ill patients with acute renal failure, in 19% of whom was sepsis identified as the presumed cause, in-hospital mortality was 37% with a combined outcome of death or dialysis dependence in 50% (3). Clinicians are challenged to manage this disease in an aging population with multiple comorbidities, immunosuppression, and a changing pattern of causative microorganisms (2,4). The increasing incidence of sepsis and the unacceptably high mortality rates associated with the disease have led to global efforts to understand pathophysiology, improve early diagnosis, and standardize management (5). Understanding the spectrum of the disease is important for gauging severity, determining prognosis, and developing methods for standardization of care in sepsis. At an international consensus conference in 1991, sepsis was defined as the systemic inflammatory response syndrome (SIRS) with a suspected source of infection. SIRS is defined as two or more of the following perturbations: Temperature >38 or 90 beats per minute; respiratory rate >20 breaths per minute or Paco2 12,000/mm3, 10% immature band forms. Organ dysfunction and hypoperfusion abnormalities characterize severe sepsis, and septic shock includes sepsis-induced hypotension despite adequate fluid resuscitation (6). These definitions allowed for a more uniform approach to clinical trials, hypothesis generation, and the care of the patient with sepsis. The use of SIRS criteria for the identification of sepsis have been believed by many to be arbitrary and nonspecific. In 2001, …