Abstract
Improvements in survival for acute myocardial infarction, trauma, and stroke have been realized through continuous quality improvement (CQI) initiatives that include early identification and implementation of time-sensitive therapies at the earliest stage of disease presentation. In addition, challenges in the management of severe sepsis and septic shock remain in regards to implementation of an early sepsis resuscitation bundle (RB) in order to maximize outcome benefit. We examined the impact of a hospital-wide CQI initiative on septic RB compliance and outcome and investigated the mortality benefits beyond the 6-hour recommendation period.
Highlights
We previously showed that erythropoietin (EPO) attenuates the morphological signs of spinal cord ischemia/reperfusion (I/R) injury in swine [1] without, improving neurological function
The clinical use of EPO has been cautioned most recently due to serious safety concerns arising from an increased mortality in acute stroke patients treated with EPO and simultaneously receiving systemic thrombolysis [2]
We tested the hypothesis whether Carbamylated EPO (cEPO) may be efficient as EPO in reducing morphological as well as functional aortic occlusion-induced spinal cord I/R injury
Summary
We previously showed that erythropoietin (EPO) attenuates the morphological signs of spinal cord ischemia/reperfusion (I/R) injury in swine [1] without, improving neurological function. Methods We studied 90 patients affected by severe sepsis or septic shock previously enrolled in a prospective trial regarding the impact of glycemic control on inflammation and coagulation. In a retrospective analysis of the data from the SBITS-trial [1] we investigated whether the initial level of serum IgG on admission to the hospital in patients with sepsis and septic shock (before the first administration of the first dose of intravenous immunoglobulins) could be seen as a prognostic parameter for the primary outcome, lethality on day 28, or the secondary endpoints, lethality on day 7 or on the ICU. The aim of this analysis was to assess the impact of real-time continuous glucose monitoring (CGM) on glucose variability in critically ill patients receiving intensive insulin therapy (IIT) Methods This is the post hoc analysis of a prospective, randomized, controlled trial [2]. Respecting anonymity we have statistically evaluated 103 replies (response rate was 13.8%) and compared with data from other European countries
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