Abstract
Sepsis Needs Follow-Up Studies in Intensive Care Units- Another Avenue for Translational Research
Highlights
Sepsis characteristics were highlight in this mini review in order to call attention for a complex, age- independent, acute disease faced suddenly by the human body under infection or traumatic stimuli
The intensity and duration of the inflammatory response has been closely related with mortality, since once out of control inflammation leads to massive production of pro-inflammatory cytokines, which in turn leads to coagulation disorder, tissue injury, multiple organ dysfunction, and to death
Neutrophils recruitment to sites of infection is a critical element of the innate immune response, being the cells that migrate first to an infectious site responding to chemo attractants factors and cytokines
Summary
Sepsis characteristics were highlight in this mini review in order to call attention for a complex, age- independent, acute disease faced suddenly by the human body under infection or traumatic stimuli. The high mortality verified worldwide in patients with sepsis in intensive care units (ICU) is a sad social problem that needs to be solved. The intensity and duration of the inflammatory response has been closely related with mortality, since once out of control inflammation leads to massive production of pro-inflammatory cytokines, which in turn leads to coagulation disorder, tissue injury, multiple organ dysfunction, and to death.
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