Sepsis Due to Bacterial Infection: An Analysis based on Ratio Count of Neutrophil – Lymphocyte

Abstract

Sepsis due to bacterial infection is a serious medical emergency and requires prompt and proper handling. Various parameters such as white blood cells count, CRP, and PCT level are used as a marker of sepsis due to bacterial infection. Sepsis is a condition of systemic inflammation with infection. Physiological response to systemic inflammation involves an increased level of neutrophils and a reduction of lymphocyte count; therefore, combining both parameters seems logical, and NLCR could be a simple and even better marker in predicting sepsis. This research aimed to determine the sensitivity and specificity of the NLCR test in patients with sepsis due to bacterial infection. This research was conducted by observing 70 sepsis patients aged 14-70 years at a private hospital in Bekasi and UKI general hospital in July-September 2015 through medical records. This research was an observational study with a cross-sectional design. The result of this research showed ROC curve for NLCR test with sensitivity 97.8 % , specificity 84.0 % , and cut off ≥ 6,4 (AUC: 0,94, p-value <0,05). In conclusion, the NLCR is an ideal and efficient marker to diagnose sepsis due to bacterial infection with good sensitivity and specificity tests.
 Keywords: Sepsis, NLCR, Sensitivity, Specificity.