Abstract
Sepsis is a complex systemic inflammatory response syndrome caused by invasion of a variety of pathogenic bacteria.The disease spectrum includes sepsis, severe sepsis, septic shock and multiple organ failure.Mitochondria are referred to aspower plants, providing energy for viscera to maintain normal function.Immune disorders, the activation and release of a series of inflammatory factors, anomalies of intracellular signal transmission and oxidative stress in sepsis can induce mitochondrial dysfunction.Recent research suggests that mitochondrial autophagy also plays a certain role in mitochondrial dysfunction.This article reviews the mechanism of mitochondrial functional damage during the pathogenesis of sepsis. Key words: Sepsis; Mitochondrial damage; Mitochondrial autophagy
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