Abstract
Effect of anti-CD14 mAbs or IgG2a on fMLP-triggered respiratory burst of control unprimed (a) and Re-LPS primed human PML (b)
Highlights
Metabolites of aromatic amino acids - phenylcarboxylic acids (PhCAs) - significantly increased in critically ill patients with infection, especially with sepsis [1] and associated with mortality [2, 3]
The results of the study indicate that pneumonia aggravation up to destructive intrapulmonary complications and acute respiratory distress syndrome (ARDS) is mediated by polymorphisms in oxidative stress-related genes
To assess CD14 involvement in endotoxin priming of human polymorphonuclear leukocytes (PML) for fMLP-triggered respiratory burst we used the full anti-CD14 monoclonal antibodies (mAbs) containing Fc-regions
Summary
Metabolites of aromatic amino acids - phenylcarboxylic acids (PhCAs) - significantly increased in critically ill patients with infection, especially with sepsis [1] and associated with mortality [2, 3]. There are limited prospective cohort studies of suspected septic patients aimed at determining the risk associated with increased level of histones to their progression to severe sepsis. To address the need of more rapid diagnosis of potential pathogens causing sepsis or septic shock in patients, Q-linea is developing a fully automated, high-throughput diagnostic platform, ASTrID®.The system will perform both molecular pathogen identification and phenotypic antibiotic susceptibility testing (AST), directly from whole blood, delivering ID after four hours and AST in additional six. Materials/Methods In an ongoing study clinical blood samples are collected from patients suspected of having sepsis attending the Infectious Disease ER, University hospital of Örebro, Sweden. The histopathological analysis showed a reduction (P < 0.001) in reactive astrocytes and caspase 3-positive apoptotic cells
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