Abstract
The level of sepiapterin reductase (EC 1.1.1.153) activity in blood of various animals was examined with special reference to dihydrofolate reductase activity. Both enzyme activities in liver were determined for comparison. In all animal species tested, the activity of sepiapterin reductase was only found in erythrocytes though dihydrofolate reductase was found in both erythrocytes and leucocytes. The rat seemed peculiar in its high activity of sepiapterin reductase in erythrocytes and liver. Both enzyme activities were also examined in blood corpuscles and ascites tumor cells of three lines of rat with transplantable leukemias. In leucocytes of leukemic rats, no measurable activity of sepiapterin reductase was found, while the level of dihydrofolate reductase was about 2 times higher than that of normal. Ascites tumor cells showed significant activities of both enzymes.
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