Abstract
This paper studies the coupling of simulated moving bed (SMB) chromatography with crystallization for the separation of Tröger’s base enantiomers. SMB is used to achieve a certain level of enrichment and then evaporative crystallization of the extract and raffinate streams leads to the final product with the specified purity. The optimization of the combined process is based on thermodynamic data about adsorption isotherms of the two enantiomers in ethanol on microcrystalline cellulose triacetate (CTA) and about solubility of the two enantiomers in ethanol. The results, obtained using a genetic algorithm, prove that there is an optimal value of the purity achieved in the SMB that maximizes the productivity of the combined process.
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