Abstract
Nearly complete tolerance to a test dose of 50 μg/kg of LSD occurred within 24 h following an initial dose of 50 μg/kg of the drug, using limb flicking and abortive grooming as behavioral indices in the cat. No changes in serotonin receptor binding were observed at this time. However, chronic administration of LSD (50 μg/kg every 12 h for 6 days) produced a significant decrease in serotonin receptor binding in both the forebrain and brainstem plus spinal cord. These data suggest that the behavioral effects of LSD and tolerance to LSD as measured here are mediated predominantly by different sites.
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