Abstract
The present studies were designed t o determine the effects of ethane-1,1-diphos-phonic acid (EHDPTM), an analog of pyrophos-phate, on the hypocalcemic and hypophosphatemic actions of salmon calcitonin (SCT). Rats were pretreated for 3 or 4 days with daily subcutaneous (sc) injections of EHDP (40 mg/kg body wt). 45Ca was administered (intraperitoneally) 10 days prior to EHDP treatment and 32P (intravenously) the day following the last injection of the drug. SCT (0.4 MRC mU/g body wt) was injected sc 1 hr after 32-P administration. Preliminary tests with thfS drug had confirmed that the dosage used at least partially inhibited the 45Ca removal from bone stimulated by low-calcium diet or parathyroid hormone administration; and at least partially reduced the uptake of both 45Ca and 32P by bone, during the first 5 hr after intravenous administration of isotopes. Following SCT injection plasma calcium concentrations fell only 5% in EHDP-treated rats compared to 25% in rats not treated with EHDP. Plasma phospha...
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