Abstract
Previous attempts to resolve the closely related taxanes cephalomannine and taxol by reversed-phase high-performance liquid chromatography (HPLC) on octadecyl silica columns have not been successful. In the present study, high-resolution HPLC on microcolumns packed with octadecyl silica was evaluated for the separation of the aforementioned taxanes. Due to the enhanced separation efficiency of this technique, baseline resolution between cephalomannine and taxol was readily achieved under isocratic elution conditions. Chromatographic profiles of Taxus brevifolia twig and needle foliage extracts are presented that illustrate this separation.
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