Abstract
The separation of some propranolol analogues I into their enantiomers and diastereomers respectively, by HPLC succeeded with cellulose tris(3,5-dimethylphenylcarbamate) as a chiral stationary phase and hexane-alcohol and aqueous NaClO 4-acetonitrile as mobile phases. Retention times and α values depend on the substituents R 1 and R 2. With non-aromatic substituents R 1 or R 2 the R-enantiomers are eluted first whereas with aromatic substituents the S-enantiomers, surprisingly, have shorter retention times.
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