Abstract
Sindbis virus variants which differ in plaque-type, virulence, and neuroinvasiveness in mice have been separated into two distinct hemagglutinating peaks by calcium phosphate chromatography. The large plaque variant begins to elute from the column at a phosphate molarity of 0.4 m and the small plaque variant begins to elute at 0.28 m phosphate. Variants producing large plaques predominated in the first peak in a ratio of 10 to 1, whereas variants producing small plaques were concentrated in the second peak at approximately the same ratio. These differences in elution profiles obtained from chromatography on calcium phosphate indicated that these variants differ in surface structure or composition.
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