Abstract
Abstract : In recent years the number of 2,5-epipolythia-3,6-dioxopiperazine antibiotics has increased significantly due to isolation of new members of the series and by chemical transformations of the naturally-occurring compounds. By extensive chemical and/or X-ray crystallographic investigations the structure of gliotoxin (I), sporidesmin (II, X = 2, R = OH) and dehydrogliotoxin (III, X = 2) was determined and other closely related compounds have since been isolated or synthesized. The report deals with the thin-layer chromatographic behavior of fifteen of these sulfur-containing compounds. The separation of polysulfides (II, X = 1, 2, 3, 4, R = OH) and (III, X = 1, 2, 3, 4) differing only in the number of sulfur atoms in the 2,5 bridge is particularly noted. (Author)
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