Abstract
To calculate regional myocardial blood flow, ensemble ICA (independent component analysis) was evaluated. Myocardial blood flow was estimated from dynamic H/sub 2//sup 15/O PET, and perfusion score was computed from myocardial SPECT data in this study. In ensemble ICA, posterior pdf was approximated by a rectified Gaussian distribution to incorporate non-negativity constraint, which is suitable to dynamic images in nuclear medicine. Major cardiac components were separated successfully by the ensemble ICA method. Mean myocardial blood flow was 1.2/spl plusmn/0.40 ml/min/g in rest, 1.85/spl plusmn/1.12 ml/min/g in stress state. Reproducibility of data analysis for blood flow values were highly correlated (r=0.99). The image contrast between left ventricle and myocardium was better than other method. Perfusion reserve was decreased in the stenosis region. Applied ensemble ICA method will be a feasible method to handle dynamic image sequence obtained by the nuclear medicine techniques.
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