Abstract
In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-α-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors α m with the interaction strengths R m. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization.
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