Abstract
Chronic low-frequency stimulation elicits in rabbit fast-twitch muscle a partial inactivation of the sarcoplasmic reticulum (SR) Ca 2+-ATPase and Ca 2+-uptake activities. Inactive Ca 2+-ATPase was enriched in a light microsomal fraction by sucrose density gradient centrifugation after calcium oxalate loading in the presence of ATP. This fraction showed a reduced specific activity and phosphoprotein formation of the Ca 2+-transport ATPase. These results suggest that the inactivation of the Ca 2+-ATPase as induced by increased contractile activity, is confined to a specific SR vesicle population.
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