Separation methods for system‐wide profiling of protein terminome

Publication Date Sep 1, 2022


Protein N- and C-termini have specific biochemical properties and functions. They play vital roles in various biological processes, such as protein stability and localization. In addition, post-translational modifications and proteolytic processing generate different proteoforms at protein termini. In recent years, terminomics has attracted significant attention, and numerous strategies have been developed to achieve high-throughput and global terminomics analysis. This review summarizes the recent protein N-termini and C-termini enrichment methods and their application in different samples. We also look ahead further application of terminomics in profiling protease substrates and discovery of disease biomarkers and therapeutic targets.


Discovery Of Disease Biomarkers Protein Termini Numerous Strategies Protein Stability Post-translational Modifications Biological Processes Therapeutic Targets Discovery Of Targets Discovery Of Biomarkers Biochemical Functions

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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