Abstract
AbstractA molecule of a medicinal substance displays its pharmacological properties due to interaction with biotargets in a living organism such as enzymes, receptors, various elements of cellular membranes and endogenous macromolecules. The pharmacological effects of several isomers of a substance may be different due to steric differences. For example, enantiomers of some amino acids (D-isomers) are biologically inert and are excreted from the body unchanged. Synthomycine, an antibiotic for external application, is represented by two stereoisomers. D-(–)-threo-form (naturally occurring chloramphenicol) is the active form and L-(+)-threo-form is practically inactive.
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