Abstract
Separation and purification of biomacromolecules either in biopharmaceuticals and fine chemicals manufacturing, or in diagnostics and biological characterization, can substantially benefit from application of microfluidic devices.
Highlights
Over the past two decades, microfluidic devices have been the focus of numerous studies due to their ability to process fluids either for analyses, reactions or separations in a very efficient and controllable way
This review aims at discussing some basic phenomena underlying benefits of microfluidic devices and their use in extraction and separation of proteins and nucleic acids with the emphasis on liquid–liquid extraction (LLE)
The microfluidics concept was firstly proposed in 1969 by Lew and Fung[23] without being completely aware of the microfluidic phenomenon per se. These authors demonstrated that thecirculation flow within the blood vessels and the air flow within the bronchioles and alveolar ducts and sacs of the lungs were subjected to a change upon the entry of a new vessel or branch, respectively, and that this flow was determined by the low Reynolds numbers (Re)
Summary
TUTORIAL REVIEW Sónia P. M. Ventura, Polona Žnidaršič-Plazl et al Separation and purification of biomacromolecules based on microfluidics Open Access Article. Published on 19 March 2020. Downloaded on 10/5/2020 6:30:12 PM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
