Abstract
A number of commonly used sympathomimetic amines have been subjected to gas chromatographic analysis on low-loaded columns. With the exception of certain isomers, most compounds can be separated on a column of silicone rubber SE-30. Many of the amines investigated react with ketones and the products produce sharp, symmetrical peaks on the gas chromatogram. Ephedrine and pseudoephedrine can be separated and identified on the basis of the difference in the rate of reaction with acetone. Monohydroxyphenols show strong adsorptive effects as the free bases but can readily be gas chromatographed as the acetone derivatives. The dihydroxyphenols are converted to the triacetyl derivatives which are treated with hexamethyldisilazane prior to the gas chromatographic analysis.
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