Abstract
Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids—ajugasterone C, 20-hydroxyecdysone and polypodine B—from the Serratula coronata (S. coronata) herb were separated by column chromatography, identified by spectroscopic data and quantified by high-performance liquid chromatography with a diode array detector (HPLC-DAD). The obtained concentration of ecdysteroids (approximately 23%) in the S. coronatae herb extract enhances the possibility of their use in pharmaceutical and cosmetic products with high levels of phytoecdysteroids. Moreover, this study has shown a positive effect of ecdysteroids-containing cream on changes in quality of life and a beneficial effect in reducing the symptoms of seborrheic dermatitis. It has been demonstrated that the application of the cream with phytoecdysteroids resulted in a statistically significant alleviation of symptoms (p < 0.05), especially in terms of itching, pain or burning sensations in the affected areas in comparison to previous symptoms.
Highlights
IntroductionPhytoecdysteroids are a class of chemical compounds (triterpenoids) that are synthesized by plants for defense against insects
Phytoecdysteroids are a class of chemical compounds that are synthesized by plants for defense against insects
In this study, we focused on the use of main phytoecdysteroids isolated from the Serratula coronate herb for skin disorders such as Seborrheic dermatitis (SD)
Summary
Phytoecdysteroids are a class of chemical compounds (triterpenoids) that are synthesized by plants for defense against insects. Over 300 plant ecdysteroid analogues have been identified so far with distinctive chemical, physical and biological properties. These compounds are derivatives of cyclopentane perhydrophenantrene. The vast majority of them have 27 atoms of carbon, with a double bond between C7–C8 and a keto group on C6. Ecdysteroids are characterized by methyl groups on C10 and C13 in the ß configuration and by the double bond between C7–C8. Ecdysteroids isolated from the Centaureinae subtribe plants are further characterized by two OH groups on C2
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