Abstract
Three types of triglycerides were isolated from the plasma of a patient with Refsum's disease: one without, one with 1 and one with 2 moles of phytanic acid per mole of glycerol. Glyceryl triphytanate was missing. Five triglycerides containing phytanic acid in different positions were synthesized and compared by thin-layer chromatography with those of the patient. A new method was used for the analysis of glycerol and fatty acids of triglycerides. Competition between phytanic acid and linoleic acid for binding sites in plasma triglycerides may be responsible for the low linoleic acid content in adipose tissue of patients with Refsum's disease.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
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