Separación de componentes química (toxina botulínica tipo A) en la reparación de hernia ventral planeada: un modelo murino

Abstract

IntroductionPlanned ventral hernias are produced when the abdominal fascial layer has been left unclosed and the abdominal viscera are covered only with grafted skin, associated with retraction of the lateral muscles of the abdominal. In this study we use the chemical component separation with botulinum toxin A (BTA) with the objective to modify the hernia defect area and the abdominal wall tension, as well as to verify if it is possible a major compliance of the abdominal wall in a mice model. Material and methodsFourteen rats were selected, which were divided into 2 groups randomly. We performed a planned ventral hernia to each group, 3 weeks later we injected saline solution in the lateral muscles of the abdominal wall to the I group (n=7) and to the II group (n=7) BTA in the same place. Subsequently, 2 weeks later we analyzed and measured the variables; hernia area defect, tension and compliance of the abdominal wall. ResultsA decrease on the tension of the abdominal wall with the use of BTA was found (right side 0.453±0.83N vs 0.222±0.020N, P<.001, left side 0.505±0.130N vs 0.207±0.020N, P=.001), likewise in the abdominal wall compliance (69.14±9.90mmHg vs 111.43±10.69mmHg, P<.001). On the diminish of the hernia defect area, no statistically significance differences were found. ConclusionsChemical component separation with BTA causes a decrease in the tension of the abdominal wall and allows a greater compliance of the abdominal wall, achieving a hernia defect closure with less tension.