Abstract
Glioblastoma (GB) is the most common brain malignancy and accounts for over 50% of all high-grade gliomas. Radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy is the current standard of care for patients with newly diagnosed GB up to age 70. Recently, a new standard of care has been adopted for elderly patients (≥ 65 years) based on short course of RT and TMZ. Several clinically relevant molecular markers that assist in diagnosis and prognosis have recently been identified. The treatment for recurrent GB is not well defined, and decision-making is usually based on prior strategies as well as several clinical and radiological factors. The presence of neurologic deficits and seizures can significantly impact quality of life.
Highlights
Glioblastoma (GB) is the most common and the most aggressive primary brain tumor with an incidence of 3–5 cases per 100,000 inhabitants per year and a slight predominance in males. 4000 new cases of malignant gliomas are diagnosed each year in Spain, from which more than one-third are GB [1]
Glioblastoma (GB) is the most common brain malignancy and accounts for over 50% of all high-grade gliomas
Radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy is the current standard of care for patients with newly diagnosed GB up to age 70
Summary
Glioblastoma (GB) is the most common and the most aggressive primary brain tumor with an incidence of 3–5 cases per 100,000 inhabitants per year and a slight predominance in males. 4000 new cases of malignant gliomas are diagnosed each year in Spain, from which more than one-third are GB [1]. 4000 new cases of malignant gliomas are diagnosed each year in Spain, from which more than one-third are GB [1]. GB may develop at all ages, with the peak incidence in the sixth decade of life; and the mean age at diagnosis of 62 years. Rare hereditary syndromes confer an increased risk for glioma such as neurofibromatosis type 1, Cowden, Turcot, Lynch and Li-Fraumeni syndromes.
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