Abstract

Introduction: Allergic rhinitis is an inflammatory disease of the nasal mucosa that most often occurs in children and it is a growing global health problem. Aim: Aim of the study was to examine the sensitization on inhalant allergens in children with allergic rhinitis and its association with asthma. Methods: We performed a cross-sectional study using data from our hospital records (2018-2022). A total of 412 children with symptoms of allergic rhinitis participated in the study, aged from 4 to 17 years old. The presence of allergic rhinitis was evaluated by specialist of allergology, immunology and otorhinolaryngology. The diagnosis was made on personal and family history, physical examination of the patient, skin prick tests and laboratory parameters. Results: Out of 412 children enrolled in the study, 205 (55.1%) were male. All were diagnosed with allergic rhinitis, while 168 (40.78%) were, in addition to allergic rhinitis, diagnosed with bronchial asthma 66.26% (N=273). Hypersensitivity to the inhalant allergens according to positive skin prick test was found as follows: Dermatophagoides pteronyssinus (67.96%; N=280 subjects), Ambrosia artemisiifolia (62.87%; N=259 subjects), Betula (54.13%; N=223 subjects) Corylus (52.91%; N=218) and grass pollen (52.91%; N=218 subjects).Hypersensitivity to the inhalant allergens according to higher levels of specific IgE was found as follows: Dermatophagoides pteronyssinus (66.26%; N=273), Ambrosia artemisiifolia (66.02%; N=272), Betula (57.52%; N=237), Corylus (55.34%; N=228), Poa pratensis (45.39%; N=187), Artemisia vulgaris (27.67%; N=114), Phelum pratense (25.46%; N=105), cat dander (28.64%; N=118) and dog dander (23.54%; N=87). Conclusion: Our data suggest that sensitization on house dust mite has important role in development of allergic rhinitis. Most children have allergic rhinitis linked to asthma.

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