Abstract
The potential immunotoxicity of xenobiotics has been the focus of a growing concern during the past decade. Even though a large number of experimental studies, mainly in rodents, suggested that the immune system is a likely target organ of toxicity for many pharmaceutical products and occupational as well as environmental chemicals (Descotes 1988), little is actually known of their immunotoxic effects in man (Newcombe et al. 1992; Burrell et al. 1992). Among possible approaches to identify those chemical exposures more likely to induce immunotoxic effects, namely clinical consequences associated with immunosuppression and immunostimulation, hypersensitivity, and autoimmunity, biomarkers of immunotoxicity have been first considered for use. Sentinel screening is proposed as an alternative to biomarkers that are still poorly, if at all, standardized and validated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
