Abstract
The authors have determined that epineurial arterioles of the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation. Using immunohistochemistry, the authors determined that nerves innervating epineurial arterioles contain the neuropeptide calcitonin gene–related peptide (CGRP). Using streptozotocin-induced diabetic rats, the authors demonstrated that CGRP content in sensory nerves innervating epineurial arterioles and vasodilation in response to exogenous CGRP was decreased. In summary, epineurial arterioles of the sciatic nerve are innervated by sensory nerves containing the neuropeptide CGRP. The diabetes-like condition induced by streptozotocin reduces the content of CGRP in these nerves and exogenous CGRPmediated vasodilation. CGRP is likely an important regulator of vascular tone and compromising its function could contribute to nerve ischemia and diabetic neuropathy.
Highlights
The authors have determined that epineurial arterioles of the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation
Vasodilation induced by calcitonin gene–related peptide (CGRP) was impaired to a greater extent in epineurial arterioles derived from diabetic rats of 10- to 12-week duration compared to arterioles from 4- to 6-week diabetic rats (+P < .05 compared to 4- to 6-week diabetic rats)
Our studies have shown that streptozotocin-induced diabetes, 10- to 12-week duration, caused both a decrease in the CGRP content in epineurial arterioles and the ability of exogenous CGRP to induce vasodilation
Summary
The authors have determined that epineurial arterioles of the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation. The authors determined that nerves innervating epineurial arterioles contain the neuropeptide calcitonin gene–related peptide (CGRP). Using streptozotocin-induced diabetic rats, the authors demonstrated that CGRP content in sensory nerves innervating epineurial arterioles and vasodilation in response to exogenous CGRP was decreased. Epineurial arterioles of the sciatic nerve are innervated by sensory nerves containing the neuropeptide CGRP. The diabetes-like condition induced by streptozotocin reduces the content of CGRP in these nerves and exogenous CGRPmediated vasodilation. Our studies indicate that epineurial arterioles of the sciatic nerve are innervated with sensory afferent nerves containing the vasoactive peptide CGRP. Reported that diabetes caused deficits in both anterograde and retrograde axonal transport of CGRP and a 30% to 40% decrease in the content of CGRP in the sciatic nerve, which was prevented by insulin treatment [13,14,15]
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