Sensory feedback contributes to early movement-evoked fields during voluntary finger movements in humans

Abstract

Neuromagnetic field changes accompanying voluntary movement in humans (`movement-evoked fields' or MEFs) were recorded over the scalp using a whole-head MEG system during the performance of self-paced finger movements in order to determine the contribution of sensory feedback to the generation of these brain responses. It was found that cooling the subject's arm resulted in delays of 8 ms or more in the latency of the early movement-evoked field component (MEFI). These delays were attributed to increases in conduction times in the afferent pathways as confirmed by electrically evoked somatosensory responses and suggest a peripheral origin of the MEFI. In a second experiment, we demonstrated the effects of sensory input to the contralateral hand during a simple button pressing task in 4 subjects. The results indicated that responses over the hemisphere ipsilateral to the side of movement which resembled previously reported ipsilateral MEFs can be elicited by the spread of mechanical stimulation to opposite side of the body when a mechanical trigger is used. These experiments provide further evidence that early movement-evoked fields produced by unilateral finger movements are observed primarily over the contralateral somatosensory cortex and represent sensory feedback to the somatosensory cortex from the periphery.