Abstract
Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.
Highlights
Sensory circuits provide essential components for accurate movement, including texture discrimination, spatial awareness, object perception, and tactile feedback (Abraira and Ginty, 2013)
Proprioceptive feedback transmitted through the dorsal column-medial lemniscal system is essential for movement control in healthy and injury conditions (Pearson, 1995; Windhorst, 2007; Tuthill and Azim, 2018)
Proprioceptive and mechanoreceptive circuits are known to remodel below the level of spinal cord injury (SCI), providing an alternative circuit for transmission of afferent information (Hollis et al, 2015; Granier et al, 2020)
Summary
Reviewed by: Aritra Kundu, University of Texas at Austin, United States Marin Manuel, Université Paris Descartes, France. Specialty section: This article was submitted to Neuroprosthetics, a section of the journal Frontiers in Neuroscience. Received: 01 October 2021 Accepted: 10 November 2021 Published: 08 December 2021. Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement
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