Sensory and autonomic nervous system dysfunction in amyotrophic lateral sclerosis.

Abstract

Amyotrophic lateral sclerosis (ALS) has been traditionally regarded as a progressive neurodegenerative disorder of the motor system. Clinically, ALS is characterised by a combination upper motor neuron [UMN] (brisk deep tendon reflexes, spasticity and extensor plantar response) and lower motor neuron [LMN] signs (fasciculations, muscle wasting and weakness), which form the basis of the ALS diagnostic criteria. This article is protected by copyright. All rights reserved.