Sensors for the detection of ammonia as a potential biomarker for health screening

Peter P Ricci,Otto J Gregory

doi:10.1038/s41598-021-86686-1

Abstract

The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO2) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications.

Highlights

The decomposition products interact with the metal oxide catalyst resulting in selective redox reactions and a second heat effect
Several platforms exist that are capable of detecting ammonia in the vapor phase at very low concentrations
Detection of ammonia has been achieved through other analytical techniques including s pectroscopy[21,22,23], ion mobility s pectrometry[24,25,26], and gas chromatography[27]

Summary

Introduction

The decomposition products interact with the metal oxide catalyst resulting in selective redox reactions and a second heat effect. Both heat effects release energy causing a change in electrical power required to maintain the sensor temperature setpoint. Oxidation reactions are known to release heat producing negative responses as the electrical power required to maintain the sensor temperature is decreased.

Results

Conclusion