Abstract
Micro and nanoparticles are not only understood as components of materials but as small functional units too. Particles can be designed for the primary transduction of physical and chemical signals and, therefore, become a valuable component in sensing systems. Due to their small size, they are particularly interesting for sensing in microfluidic systems, in microarray arrangements and in miniaturized biotechnological systems and microreactors, in general. Here, an overview of the recent development in the preparation of micro and nanoparticles for sensing purposes in microfluidics and application of particles in various microfluidic devices is presented. The concept of sensor particles is particularly useful for combining a direct contact between cells, biomolecules and media with a contactless optical readout. In addition to the construction and synthesis of micro and nanoparticles with transducer functions, examples of chemical and biological applications are reported.
Highlights
The development of micro and nanoparticles is motivated by the desire for new materials, but mainly driven by particle-specific functional properties
This review provides an overview of the development of synthesis of micro and nanoparticles with transducer properties and application of these particles in microfluidic systems
Fluorescent gold nanoclusters functionalized with bovine serum albumin (BSA-AuNCs) and gold nanoparticle embedded with Rhodamine 6G (RB-AuNPs) were
Summary
The development of micro and nanoparticles is motivated by the desire for new materials, but mainly driven by particle-specific functional properties. The introduction of particle-based transduction opens new possibilities, too These are related to the special functional properties of the applied particles and the fact that specific physical effects can become usable for the conversion of signals in the lower micron and, in particular, in the nanometer range. This concerns, for example, size- and shape-dependences of optical properties of particles offering advantages for surface-enhanced Raman scattering (SERS) or so-called plasmonic sensing [4]. The principles of microchannel-based and capillary-based microfluidic devices and examples of their application in the synthesis of organic, inorganic particles or various composed nanoparticles are discussed
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