Abstract
BackgroundUp to now very few data on allergic sensitization to rodent allergens in Western Europe and Italy are available, and there are no information at district level.The aim of this report was to investigate clinical significance and characteristics of allergic sensitization to mouse/rat (M/Rt) allergens in atopic subjects living in Campania district (Southern Italy).MethodsAllergists from the whole Campania district were required to report the results of skin prick tests of at least 100 consecutive subjects. In 1,477 consecutive outpatients, we selected all subjects with an immediate skin reaction to M/Rt dander. Clinical history including a careful evaluation of the modality of exposure and the results of skin-prick tests (SPTs) were recorded.ResultsFifty seven patients were sensitized to M/Rt dander (5.78%). Two patients were mono-sensitized. Fourteen patients reported indoor conditions suggesting presence of rodents allergens at home. All patients exhibited low-moderate degree of SPT positivity to M/Rt. High frequency of concomitant allergic sensitization to dust mites was found.ConclusionsOur results suggest that the role of allergic sensitization to rodents is not negligible in atopic subjects without occupational exposure living in Campania district area; these values are higher in comparison to those previously found in Naples area. Highly atopic individuals should be tested by SPTs/evaluation of serum specific IgE to rodents in the case they should begin an occupational exposure to M/Rt or keep these animals as pets.
Highlights
Up to now very few data on allergic sensitization to rodent allergens in Western Europe and Italy are available, and there are no information at district level
To perform a prospective study for assessing the prevalence of allergic sensitization, clinical characteristics and modality of exposure to common rodents (M/Rt) in a sample of atopic population without occupational exposure living in Campania district area (Southern Italy)
Fourteen out of 57 patients reported some indoor conditions which constitute predictors for the presence of rodents allergens. In four of these individuals we found the higher levels of cutaneous sensitization to M/Rt, the remaining patients exhibited low/moderate degree of skin-prick tests (SPTs) positivity
Summary
Up to now very few data on allergic sensitization to rodent allergens in Western Europe and Italy are available, and there are no information at district level. The aim of this report was to investigate clinical significance and characteristics of allergic sensitization to mouse/rat (M/ Rt) allergens in atopic subjects living in Campania district (Southern Italy). Rodents (mouse and rats - M and Rt) are a well recognized cause of IgE-mediated sensitization and bronchial asthma in several occupationally exposed individuals such as research scientists, technicians and animal handlers [1]. Campania district to perform a prospective study for assessing the prevalence of allergic sensitization, clinical characteristics and modality of exposure to common rodents (M/Rt) in a sample of atopic population without occupational exposure living in Campania district area (Southern Italy)
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